Linea 2 – Basi neurofisiologiche del comportamento

La linea di ricerca 2 contribuisce alla conoscenza delle basi fisiologiche dell’attività neurale dei processi sensoriali e cognitivi che possono essere compromessi in pazienti neurologici.

Le attività della linea coinvolgono lo studio dei meccanismi di recupero funzionale mediante tecniche neurofisiologiche e la verifica dell’efficacia dei trattamenti di neuromodulazione per il trattamento delle patologie neurologiche.

In neuroriabilitazione, l’uso di metodiche di indagine neurofisiologica permette di migliorare la definizione diagnostica e prognostica nonché la scelta dei trattamenti più idonei ad ottimizzare il recupero funzionale.

Per tali scopi la linea di ricerca si avvale principalmente del supporto dei laboratori di Neurofisiologia e di Neuroimmagini.

Contatti del Responsabile di Linea

Giorgio Arcara

Giorgio Arcara

Responsabile di Linea

Progetti di ricerca:

Brain connectivity measured with high-density electroencephalography: a novel neurodiagnostic tool for stroke

Dante Mantini

2018

Tipo di grant:

Ricerca finalizzata

Ente finanziatore:

Ministero della salute

By advancing the knowledge of how local damage in the brain alters the functioning of distant regions, the work has the potential to improve/enhance the account of how brain lesions produce behavioural deficits. Accordingly, the work may have a significant impact on clinicians dealing with both short- and long-term effects of brain damage. The project will not only advance the technological analysis of stroke recovery, but also provide new insights that can help design rehabilitation protocols for the future. This translational aspect has important consequences for human health, as well as potential economical spin-offs.

Assessment and treatment of communicative pragmatic abilities in neurological and psychiatric disorders: feasibility and clinical efficacy

Giorgio Arcara

2018

Tipo di grant:

Ricerca finalizzata

Ente finanziatore:

Ministero della salute

Adopting a novel transdisciplinary and transdiagnostic approach to communicative impairment, this project will provide:1) the first brief pragmatic test, easy to implement at low cost in the NHS as diagnostic and outcome tool; 2) the first comprehensive pragmatic treatment for RHD and TBI patients, adapted in individual sessions, with tested efficacy; 3) reliable and low-cost information on the neural correlates of pragmatics. Results will fill in important gaps in the clinical management of currently neglected communication disorders that affect a wide range of neurological and psychiatric populations. Moreover, the project will also innovatively consider the impact of pragmatic language disorder on patients’ as well as carers’ quality of life. Further significance will come from the study of the EEG correlates of pragmatic deficit. This will contribute to foster a better understanding of the brain basis of pragmatics and to pave the way towards new biomarkers and treatment targets.

The treatment of persistent developmental stuttering: shaping of motor neural functioning to improve fluency

Pierpaolo Busan

2018a

Tipo di grant:

Ricerca finalizzata

Ente finanziatore:

Ministero della salute

The project will provide breakthrough advance in the study of DS neural mechanisms, with impact on treatment. The present consortium may be the only one working on the neurophysiology aspects and neuromodulatory treatment of DS in Italy. Results will be translated into new treatments, with an impact on quality of life, social/career opportunities for people who suffer from this under-evaluated impairment. Innovation is granted by the collaboration with IIT that is developing a portable/safe/easy-to-use/low-cost tES. From the patients’ side, this new neurostimulation system will make it possible to self-administer neuromodulatory treatments in a controlled way. The system will prompt patients to undergo treatment, monitor its use through a direct communication with clinicians before/after each session via an in-app, text-based chat. From the clinicians¿ side, the app will allow loading of specific stimulation protocols, designing new ones and monitoring compliance with treatment.

Pre-surgical cerebral mapping for neurosurgical treatment of patients with neuroncological disease or drug-resistant epilepsy

Giovanni Pellegrino

2019-

36 mesi

Linea di ricerca:

NEUROFISIOLOGIA CLINICA

Altre strutture coinvolte:

/

Altri enti coinvolti:

/

Tipo di grant:

Ricerca corrente

Ente finanziatore:

Ministero della salute

 

This project aims to use a combination of multiple brain mapping techniques and non-invasive brain stimulation for the study of epileptic patients. In this regard, particular attention will be given to magnetoencephalography, a brain mapping technique based on the detection of magnetic fields produced by populations of neurons. This technology, approved for clinical study in the USA and in the course of clinical validation in Europe, is non-invasive, has excellent temporal resolution and good spatial resolution. Magnetoencephalography will be combined with the more traditional electroencephalography to develop fusion methods for electroencephalographic and magnetoencephalographic signals. These two methods will also be associated with brain magnetic resonance (brain anatomy) and non-invasive brain stimulation techniques, such as transcranial direct current stimulation and transcranial magnetic stimulation. The methodological validation of the proposed techniques will require the study of both patients with epilepsy and healthy subjects.

Fighting muscle atrophy

Andrea Marcante

2018-

36 mesi

Linea di ricerca:

NEUROFISIOLOGIA CLINICA

Altre strutture coinvolte:

/

Altri enti coinvolti:

Centro di Ricerca Interdipartimentale di Miologia (CIR-Myo), Dipartimento di Scienze Biomediche, Università di Padova

Tipo di grant:

Ricerca corrente

Ente finanziatore:

Ministero della salute

The project aims to detect structural changes in muscle tissue by the use of electrostimulation methods in hospitalization and home care and to study any further effects of treatment in other tissues and at the level of arterial microcirculation in patients suffering from nerve lesions of the second motion neuron.

Inter-hemispheric modulation through neurostimulation and neurofeedback as a tool to improve cognition

Antonio Vallesi

2019-

36 mesi

Linea di ricerca:

NEUROFISIOLOGIA CLINICA

Altre strutture coinvolte:

/

Altri enti coinvolti:

Dept. of Neurosciences, University of Padova

Tipo di grant:

Ricerca corrente

Ente finanziatore:

Ministero della salute

The overarching aim of this project is to systematically investigate how inter-hemispheric connectivity underlying executive functioning could be boosted in healthy individuals when facing different task demands, and restored in pathological conditions. By discovering causal links between the codes used by homologous fronto-parietal networks to communicate with each other and executive functioning, this project will help developing new theory-driven and biologically plausible rehabilitation protocols

New therapeutic approaches to promote neuronal plasticity and motor recovery in stroke patients

Giovanni Pellegrino

2018-

36 mesi

Linea di ricerca:

NEUROFISIOLOGIA CLINICA

Altre strutture coinvolte:

Servizio di Risonanza Magnetica

Altri enti coinvolti:

École Polytechnique Fédérale de Lausanne

Tipo di grant:

Ricerca corrente

Ente finanziatore:

Ministero della salute

The use of tDCS to train the control of brain activity linked to motor functions could represent a new strategy of clinical rehabilitation. The first aim is to compare different tDCS montages and determine optimal setup. The secondary aim is to test the hypothesis that tDCS applied within 4 weeks after stroke in patients with light to moderate motor deficits can enhance markers of cortical repair and motor improvement in patients with stroke.

Non invasive brain stimulation in patients with evolutive and acquired language disorders

Pierpaolo Busan

2018-

24 mesi

Linea di ricerca:

NEUROFISIOLOGIA CLINICA

Altre strutture coinvolte:

/

Altri enti coinvolti:

Neuorological dept., University of Trieste (ASUITS); Dipartimento di Psicologia dello Sviluppo e della Socializzazione, Università degli Studi di Padova; Istituto Italiano di Tecnologia (IIT) presso Università degli Studi di Ferrara.

Tipo di grant:

Ricerca corrente

Ente finanziatore:

Ministero della salute

The project aims at studying and characterizing the neurophysiological functioning of the motor networks of the acquired disorder (for example non-fluent aphasia after brain damage) and evolutionary (for example stuttering) of language, through the use of investigation tools such as brain stimulation -invasive (transcranial magnetic stimulation -TMS- single pulse and double pulse).

Study of brain activity by means of functional neuroimaging in patients with disorders of consciousness

Marianna Cavinato

2018-

36 mesi

Linea di ricerca:

NEUROFISIOLOGIA CLINICA

Altre strutture coinvolte:

Neuroimaging Laboratory

Altri enti coinvolti:

/

Tipo di grant:

Ricerca corrente

Ente finanziatore:

Ministero della salute

This study is aimed at identifying the presence of residual brain activity in patients in a vegetative state and a minimal consciousness state. Previous studies of brain metabolism at rest using positron emission tomography (PET) in UWS patients have shown a uniform reduction of brain metabolic activity. In the present study, we propose to use magnetoencephalography (MEG) associated with 64-channel electroencephalography (EEG) and functional neuroimaging (fMRI) to analyze the dynamic aspects of brain activations in patients in a vegetative state or minimal conscious state. This will be done in a resting state of patients and under different external stimulation, such as non-invasive brain stimulation (tDCS/rTMS) and emotional stimuli.

Study of the contribution of magnetoencephalography as support technique for oncology neurosurgery

Giorgio Arcara

2017-

24 mesi

Linea di ricerca:

NEUROFISIOLOGIA CLINICA

Altre strutture coinvolte:

/

Altri enti coinvolti:

Dipartimento di Neuroscienze, Università degli studi di Padova.

Tipo di grant:

Ricerca corrente

Ente finanziatore:

Ministero della salute

Neurosurgery for a brain tumor presents an important challenge: the neurosurgeon aim at maximizing the tumor resection (which as associated to better clinical outcome), while preserving some core capacities of the patients, as language, which are important for the quality of life. We hypothesize to be able to successfully create new task to adequately mapping language areas in patients and in healthy participants. In particular we aim at: – perform a systematic review on the existing tasks for language mapping – Identify the better tasks and analytical methods for language mapping.

Study of the oscillatory activity associated to language and communication impairment in patients with neurological diseases

Giorgio Arcara

2018-

24 mesi

Linea di ricerca:

NEUROFISIOLOGIA CLINICA

Altre strutture coinvolte:

/

Altri enti coinvolti:

Istituto Universitario degli Studi Superiori, Pavia

Tipo di grant:

Ricerca corrente

Ente finanziatore:

Ministero della salute

We hypothesize that the test developed by our group could be able to characterize the pragamatic deficits in different pathologies and that brain activity (especially oscillations and connectivity) would be good measures to characterize the impariment and the probability to recovery after treatment. In particular we aim at: – Study the pragmatic deficits in different populations (Dyslexia, Multiple Sclerosis, Parkinson Disease – Study the brain oscillatory correlats of pragmatic abilities in patients with neurolofical diseases, using Magnetoencephalography (MEG).