The main focus of the Laboratory of Neurodegeneration is to use and combine different imaging techniques to identify useful biomarkers to track brain changes associated with neurodegenerative disorders even at a prodromal stage. This is particularly important because it may help clinicians with their diagnosis and recommendations for patients. Moreover, early identification of brain changes in at-risk participants is considered the key to developing early interventional strategies and lay the groundwork for studies in clinical populations. The Laboratory supports the research activity of other laboratories inside and outside the Institute and is supported by the facilities provided by the Hospital.
- Establish which measure (or combination of measures) is/are most useful as imaging markers for research in neurodegeneration across different diseases.
- Develop imaging markers to be translated into the clinical domain and used as measures to identify high-risk individuals for inclusion in prevention trials, but also for early diagnosis and prediction of clinical outcome and as a potential outcome of drug efficacy in clinical trials.
- Integrate imagine measures with neuropsychological and biological data to investigate healthy and pathological ageing process.